Engineers are facing increasing challenges in today's product development, because technical systems have been getting more complex in recent years due to the trend towards interconnected products, which are often realized as cyber-physical systems or systems of systems (SoS), and other influences such as an increasing level of globalization and more stringent regulations. New development approaches have emerged to handle this complexity and allow the realization of such complex systems. One of these approaches is Model-Based Systems Engineering (MBSE), which is “the formalized application of modeling to support system requirements, design, analysis, verification and validation activities beginning in the conceptual design phase and continuing throughout development and later life cycle phases” according to INCOSE. The aim of the program Advanced Systems Engineering and the CyberTech research project founded by BMBF in Germany with the participation of industry companies and universities is frontloading and holistic integration of information for development, manufacturing and operations of machines or devices, which results in increased benefits through improved, self-optimizing machines and services. In future, Advanced Systems Engineering (ASE), human-centered work design based on digitized processes and methods as well as the use of digital twins will play the decisive roles within the work culture and organizations according to the INCOSE vision 2035 and findings from the National Institute for Science and Engineering in Germany (acatech). The orientation of the project CyberTech in the context of Advanced Systems Engineering is based on the following focal points, which will be presented: - New collaborative work culture in development and production, - Consistent digital product creation and digital twin as well and - Sensor system architecture and data science as the basis for cyber-physical systems. This presentation finally outlines an approach in order to deploy MBSE and Advanced Systems Engineering successfully and highlights some best practices from industry and highlights future endeavors when it comes to Systems Engineering.