High Performance Computing (HPC) in the Cloud is now becoming more and more popular, for all kinds of complex engineering simulation workflows. The reason? Over the last 10 years, access and use of powerful CAE cloud resources became more and more automated and self-service, many of the previous cloud roadblocks have been removed by standard high-performance cloud technologies, and thus HPC as a Service in many different forms is now in every engineer’s reach. But beside all the cloud benefits there are still real hurdles to overcome. In our presentation, we will explain these remaining hurdles and how to resolve them. We will discuss major benefits for manufacturers' decision makers, IT experts, and simulation engineers and their managers. Finally, we will demonstrate the wide applicability of Cloud HPC with the aid of four different engineering use cases from four different manufacturing areas - Bugatti Rimac in the automotive industry, FLSmidth in mining and cement, Dehn in lightning, and Buro Happold in construction. These manufacturers have been using the cloud now for two to four years, and we will present a summary of their lessons learned and recommendations to provide guidance for manufacturers who are planning to move to the cloud in the next few years.