Fiber-reinforced composite applications for aerospace industry is focused on integration of computational methods for composites process modeling, material and damage modeling to reduce the cost and process development cycle time. The Integrated Computational Materials Engineering (ICME) is a vision towards the needs of large-scale manufacturing of future aerospace systems. Autoclave cure cycle effects and the evolved material properties drive the critical design parameters for subsequent applications of composite structures. Here, the curing process modeling, the spring-in effect and the mechanical loading response of a composite structure is presented to study the effects of curing parameters that can be detrimental to the deployment of real structures in various industry applications. Curing is an irreversible exothermic process that develops residual stress causing warpage and geometry distortions of composite structures. It is important to characterize the curing process and the effects of parameters involved like the applied temperature and pressure loading on the mechanical properties of the material. The in-built curing code at the homogenized macroscale is used along with the progressive damage material modeling capability within the Abaqus framework to analyze the thermo-chemical-mechanical response of the composite. Furthermore, the proposed integrated modeling framework can be used to quantify the effects of uncertain curing and material properties on the overall response of fiber-reinforced composites, an essential task in ICME of composites.