This webinar will brings together all of the emerging simulation technologies in systems thinking and MBE to look at how they will contribute to advancing engineering simulation techniques in support of Industry 4.0 and 5.0. Advanced simulation technologies and data analytics will be exploited in conjunction with cognitive computing and Cyber-Physical Systems (CPS) comprised of interacting digital, analog, physical, and human components such as autonomous vehicles and collaborative robots. In this webinar we also explore topics on how all of the engineering information associated with the design, development, testing, manufacture and operational support of advanced products that will have highly-integrated, embedded smart subsystems and components, will be interconnected as required for realistic operations via Digital Threads in Industry 4,0 and 5.0 environments.